STUDIES OF DRUGS GIVEN BEFORE ANAESTHESIA IV: ATROPINE AND HYOSCINE

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Studies of drugs given before anaesthesia XXVI: lorazepam.

Lorazepam has been studied as preanaesthetic medication given by mouth, i.m. and i.v. Sediation and side-effects and the incidence of anterograde amnesia in patients having a standard operation under methohexitone-nitrous oxide-oxygen anaesthesia were assessed. In a preliminary study of three i.m. (2-, 4- and 8-mg) and six oral (1-,2-,2.5-,4-,5- and 8-mg) doses, the optimum dose was found to be...

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Studies of drugs given before anaesthesia. XIX. The opiates.

Using Ridit analysis, a comparison was made of the overall effects of what are generally considered to be equianalgesic doses of sixteen opiates, with respect to their desired and toxic effects when given as premedication to a standard population. Four mixtures of opiates, the non-opiate diazepam and saline were also included in the analysis. Results with all individual drugs have been previous...

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Studies of drugs given before anaesthesia. IX. Morphine with tacrine.

Morphine and morphine with tacrine (tetrahydroaminacrine) have been compared when given intramuscularly as premedication, with regard to the pre-operative state of the patient, course of anaesthesia, sequelae, and effects on reactions to suxamethonium. Tacrine appeared to increase the pre-operative toxic effects of morphine, namely dizziness and nausea. During anaesthesia, hypotension was less ...

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Studies of drugs given before anaesthesia. XXI. Droperidol.

Droperidol 5 mg and 10 mg and diazepam 10 mg were compared in premedication studies with morphine 10 mg and saline. Droperidol caused less hypnosis than either morphine or diazepam, and its use was associated with a much higher incidence of anxiety among patients than was observed in the group who had received saline only. Dizziness and restlessness were also significant features of the action ...

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Studies of drugs given before anaesthesia. XII. A comparison of papaveretum and morphine.

Papaveretum 20 mg and morphine 10-20 mg, with and without the addition of hyoscine, were compared as pre-operative medication, studying also the operative and postopsrative sequelae. It is shown that the morphine content of papaveretum 20 mg is equivalent to 13.3 mg of morphine sulphate and this dose was included in the comparison. Papaveretum caused a higher incidence of pre-operative drowsine...

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ژورنال

عنوان ژورنال: British Journal of Anaesthesia

سال: 1964

ISSN: 0007-0912

DOI: 10.1093/bja/36.10.648